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ABO Incompatible Kidney Transplantation in Children
- Source :
- The Journal of Urology; January 1995, Vol. 154 Issue: 2 p914-916, 3p
- Publication Year :
- 1995
-
Abstract
- We have performed 7 pediatric kidney transplantations from living related donors of ABO incompatibility. All patients preoperatively underwent plasmapheresis with or without immunoadsorption to reduce anti-A and/or anti-B antibodies. Immunosuppression initially consisted of methylprednisolone, cyclosporine, azathioprine, antilymphocyte globulin and deoxyspergualin. At transplantation splenectomy was simultaneously performed in all patients. Median followup is 44 months (range 31 to 58). Patient and graft survival rates are 100 percent to date. There were no uncontrolled vascular rejection episodes, and post-transplant anti-A and/or anti-B antibody titers were always less than 1:32. Transplantation across the ABO blood barrier remains challenging today. However, our small series clearly shows that the preoperative reduction of ABO antibody, simultaneous splenectomy and strict immunosuppressive therapy cause successful long-term results in children.
Details
- Language :
- English
- ISSN :
- 00225347 and 15273792
- Volume :
- 154
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- The Journal of Urology
- Publication Type :
- Periodical
- Accession number :
- ejs8688503
- Full Text :
- https://doi.org/10.1016/S0022-5347(01)67202-1