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Total Synthesis, NMR Solution Structure, and Binding Model of the Potent Histone Deacetylase Inhibitor FR235222Financial support by the University of Salerno, the University of Siena, and MIUR (Rome) is gratefully acknowledged. L.G.P., I.B., and G.B. also wish to acknowledge the use of the instrumental (NMR spectroscopy and mass spectrometry) facilities of the Center of Competence in Diagnostics and Molecular Pharmaceutics supported by Regione Campania (Italy) through POR funds. L.G.P. thanks Professor R. Abagyan for the use of ICM 3.2 (The Scripps Research Institute and Molsoft LLC, La Jolla, USA). We thank undergraduates P. De Nicola, M. De Vito, and F. Cristofano for technical assistance.
- Source :
- Angewandte Chemie. International Edition; January 2006, Vol. 45 Issue: 3 p423-427, 5p
- Publication Year :
- 2006
-
Abstract
- No Abstract
Details
- Language :
- English
- ISSN :
- 14337851 and 15213773
- Volume :
- 45
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Angewandte Chemie. International Edition
- Publication Type :
- Periodical
- Accession number :
- ejs8370159
- Full Text :
- https://doi.org/10.1002/anie.200501995