Extraction, Hemisynthesis, and Synthesis of Canthin-6-one Analogues. Evaluation of Their Antifungal Activities

Zanthoxylum chiloperone var. angustifolium was investigated. Alkaloids <BO>1</BO>−<BO>3</BO> from the canthin-6-one series were characterized. Derivatives <BO>7</BO>−<BO>28</BO> were prepared by hemisynthesis or total synthesis. All compounds were tested for in vitro antifungal activities against five pathogenic fungal strains. Analogues of canthin-6-one did not show better antifungal activities.