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Role of Alginate O Acetylation in Resistance of Mucoid Pseudomonas aeruginosato Opsonic Phagocytosis
- Source :
- Infection and Immunity; March 2001, Vol. 69 Issue: 3 p1895-1901, 7p
- Publication Year :
- 2001
-
Abstract
- ABSTRACTEstablishment and maintenance of chronic lung infections with mucoid Pseudomonas aeruginosain patients with cystic fibrosis (CF) require that the bacteria avoid host defenses. Elaboration of the extracellular, O-acetylated mucoid exopolysaccharide, or alginate, is a major microbial factor in resistance to immune effectors. Here we show that O acetylation of alginate maximizes the resistance of mucoid P. aeruginosato antibody-independent opsonic killing and is the molecular basis for the resistance of mucoid P. aeruginosato normally nonopsonic but alginate-specific antibodies found in normal human sera and sera of infected CF patients. O acetylation of alginate appears to be critical for P. aeruginosaresistance to host immune effectors in CF patients.
Details
- Language :
- English
- ISSN :
- 00199567 and 10985522
- Volume :
- 69
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Infection and Immunity
- Publication Type :
- Periodical
- Accession number :
- ejs7848056
- Full Text :
- https://doi.org/10.1128/IAI.69.3.1895-1901.2001