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Azasordarins: Susceptibility of Fluconazole-Susceptible and Fluconazole-Resistant Clinical Isolates ofCandidaspp. to GW 471558
- Source :
- Antimicrobial Agents and Chemotherapy; June 2001, Vol. 45 Issue: 6 p1905-1907, 3p
- Publication Year :
- 2001
-
Abstract
- ABSTRACTThe in vitro activity of the azasordarin GW 471558 was compared with those of amphotericin B, flucytosine, itraconazole, and ketoconazole against 177 clinical isolates of Candidaspp. GW 471558 showed potent activity against Candida albicans, Candida glabrata, and Candida tropicalis, even against isolates with decreased susceptibility to azoles. Candida krusei, Candida parapsilosis, Candida lusitaniae,and Candida guilliermondiiare resistant to GW 471558 in vitro (MICs, >128 μg/ml).
Details
- Language :
- English
- ISSN :
- 00664804 and 10986596
- Volume :
- 45
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Antimicrobial Agents and Chemotherapy
- Publication Type :
- Periodical
- Accession number :
- ejs7835855
- Full Text :
- https://doi.org/10.1128/AAC.45.6.1905-1907.2001