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In Vitro Activities of DU-1102, a New Trioxaquine Derivative, against Plasmodium falciparumIsolates
- Source :
- Antimicrobial Agents and Chemotherapy; June 2001, Vol. 45 Issue: 6 p1886-1888, 3p
- Publication Year :
- 2001
-
Abstract
- ABSTRACTThe antimalarial trioxaquine derivative DU-1102, synthesized by covalent linkage between aminoquinoline and trioxane moieties, was highly active against Cameroonian isolates (mean 50% inhibitory concentration of 43 nmol/liter) of Plasmodium falciparum. There was no correlation between the responses to DU-1102 and chloroquine and only a low correlation between the responses to DU-1102 and pyrimethamine, suggesting an independent mode of action of the trioxaquine against the parasites.
Details
- Language :
- English
- ISSN :
- 00664804 and 10986596
- Volume :
- 45
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Antimicrobial Agents and Chemotherapy
- Publication Type :
- Periodical
- Accession number :
- ejs7835847
- Full Text :
- https://doi.org/10.1128/AAC.45.6.1886-1888.2001