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Solution Structure of Quinoline‐ and Pyridine‐Derived Oligoamide Foldamers
- Source :
- Chemistry - A European Journal; October 2005, Vol. 11 Issue: 21 p6135-6144, 10p
- Publication Year :
- 2005
-
Abstract
- The unambiguous elucidation of a new folded structure in solution may prove to be a very challenging task. The NMR protocols developed for solving the solution structures of α‐peptides have been applied to aliphatic β‐ and γ‐peptides but are not directly applicable to aromatic oligomers. In particular, the string of spin systems in an aromatic sequence cannot be reconstituted solely from correlations between protons. For aromatic oligomers, it is shown that the assignment of a large part of the 13C NMR spectrum through HMBC and HSQC experiments allows to unambiguously assign proton NMR spectra and in turn to interpret NOE correlations. This has been implemented both with quinoline‐ and pyridine‐derived oligoamide foldamers, and should be applicable to a wide range of oligomers including various combinations of monomers. The NOE correlations allow the unambiguous solution structure elucidation of helical conformations of oligoamides derived from pyridine and quinoline monomers showing that, in these series, the solution structures correspond very well to the structures observed in the solid state.
Details
- Language :
- English
- ISSN :
- 09476539 and 15213765
- Volume :
- 11
- Issue :
- 21
- Database :
- Supplemental Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Periodical
- Accession number :
- ejs7822334
- Full Text :
- https://doi.org/10.1002/chem.200500395