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An Efficient Reagent for the Phosphorylation of Deoxyribonucleosides, DNA Oligonucleotides, and Their Thermolytic Analogues
- Source :
- Organic Letters; September 2005, Vol. 7 Issue: 19 p4201-4204, 4p
- Publication Year :
- 2005
-
Abstract
- <UFIGR ID="ol0516263n00001">The phosphoramidite <BO>11</BO> was prepared in three steps from methyl 2-mercaptoacetate and demonstrated efficiency in the synthesis of conventional 5-/3-phosphate/thiophosphate monoester derivatives of 2-deoxyribonucleosides and DNA oligonucleotides. Moreover, the use of <BO>11</BO> has enabled the preparation of the dinucleoside phosphorothioate analogue <BO>26</BO> in high yields (>95%) with minimal cleavage (&lt;2%) of the thermolytic thiophosphate protecting group.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 7
- Issue :
- 19
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs7629301