Chemically modified tetracycline (CMT)-3 inhibits histamine release and cytokine production in mast cells: possible involvement of protein kinase C

Authors :: Sandler, C.
Ekokoski, E.
Lindstedt, K. A.
Vainio, P. J.
Finel, M.
Sorsa, T.
Kovanen, P. T.
Golub, L. M.
Eklund, K. K.
Source :: Inflammation Research; July 2005, Vol. 54 Issue: 7 p304-312, 9p
Publication Year :: 2005
Abstract: Abstract. Objective: To find novel inhibitors of mast cell function we have studied the effect of a potent, non-antimicrobial, chemically modified tetracycline, CMT-3 or COL-3, on key functions of mast cells.

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