Secondary bile acid derivatives are contributors to the fecal bile acid pool and associated with bile acid modulating nutrients

Accumulation of hydrophobic bile acids is linked with cancer development. However, derivatives of deoxycholic acid (DCA) and lithocholic acid (LCA) produced via bacterial metabolism may mitigate the proinflammatory and cytotoxic effects of hydrophobic bile acids. The impact of diet on secondary bile acid (BA) derivative production has not been determined. Therefore, associations between BA modulating nutrients and the composition of secondary BAs and their derivatives were investigated.