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Emerging strategies in tackling antimicrobial resistance in urology: Narrative review and expert opinion

Emerging strategies in tackling antimicrobial resistance in urology: Narrative review and expert opinion

Authors :
Ceccato, Tommaso
Botti, Simone
Tascini, Carlo
Lanzafame, Massimiliano
Brugnolli, Anna
Ruggera, Lorenzo
Massidda, Orietta
Racanelli, Vito
Bjerklund Johansen, Truls E
Cai, Tommaso
Source :
Urologia; 20240101, Issue: Preprints
Publication Year :
2024

Abstract

Urinary tract infections (UTIs) are highly prevalent and frequently treated with antibiotics, making antimicrobial stewardship (AMS) crucial in this field to benefit both individual patients and society. This narrative review examines recent advancements in managing urinary tract infections, focusing on AMS and antimicrobial resistance (AMR). AMS is essential in urology, where antibiotics are frequently prescribed for UTI. AMS promotes optimal antibiotic use to improve patient outcomes, control AMR, and safeguard public health. Key AMS practices in urology include selecting antibiotics at the appropriate dose and duration, especially for uncomplicated UTIs, asymptomatic bacteriuria, and catheter-associated infections. Following evidence-based guidelines, such as those from EAU and the IDSA, helps prioritize narrow-spectrum antibiotics and discourage empirical broad-spectrum use. Regular audits and feedback on antibiotic use help align practices with AMS goals, reducing inappropriate prescriptions. Multidisciplinary AMS teams, including urologists, microbiologists, and pharmacists, enhance treatment precision and antibiotic optimization in complex cases. Reassessing antibiotic therapy based on culture results after 48–72 h enables clinicians to refine treatment, minimizing unnecessary broad-spectrum use and strengthening AMS efforts in urology. In conclusion, addressing AMR in urology requires a careful approach that combines evidence-based antibiotic use, attention to local resistance patterns, and patient-specific factors. Non-antibiotic strategies for recurrent UTI prevention, judicious catheter management, and tailored treatment for complex infections are key AMS components. Emerging technologies in diagnostics and precision medicine offer tools for targeted, personalized therapy, enhancing AMS efforts, and helping to reduce reliance on broad-spectrum antibiotics.

Details

Language :
English
ISSN :
03915603 and 17246075
Issue :
Preprints
Database :
Supplemental Index
Journal :
Urologia
Publication Type :
Periodical
Accession number :
ejs68443810
Full Text :
https://doi.org/10.1177/03915603241310389