Back to Search
Start Over
Electrochemical Detection of Gentamicin Using a Reduced Graphene Oxide-Yttria Oxide (rGO@Y2O3) Nanocomposite-Based Biosensor
- Source :
- Journal of the Electrochemical Society; December 2024, Vol. 171 Issue: 12 p127510-127510, 1p
- Publication Year :
- 2024
-
Abstract
- The control of antibiotic resistance is at an alarming stage, making the detection of antibiotics as utmost importantance. A sono-chemically-synthesized reduced-graphene oxide-yttrium oxide nanocomposite (rGO@Y2O3NC) was used to develop an effective electrochemical immunosensing platform for gentamicin detection. The rGO@Y2O3NC was characterized using different techniques, providing insights into its structural and functional properties. The detection was carried out on a carbon screen printed electrode modified with rGO@Y2O3NC using differential pulse voltammetry technique. The rGO@Y2O3NC helped to enhance the electrochemical activity and the functional groups present on rGO helped in efficient electrostatic immobilization of the antibody. Protein kinase A triggered the immunologic interaction and hence helped in achieving higher sensitivity. The developed immunosensor exhibited an impressive limit of detection of 0.457 pM, with a wide range of detection from 1 pM to 100 μM with a sensitivity of 7.03 μA pM−1cm−2, representing a substantial enhancement over current technologies. Furthermore, the immunosensor demonstrated practical applicability by effective performance in spiked milk and tap water samples. This highlights its potential for real-world applications in monitoring antibiotic use and ensuring water and food quality control according to regulations.
Details
- Language :
- English
- ISSN :
- 00134651 and 19457111
- Volume :
- 171
- Issue :
- 12
- Database :
- Supplemental Index
- Journal :
- Journal of the Electrochemical Society
- Publication Type :
- Periodical
- Accession number :
- ejs68396265
- Full Text :
- https://doi.org/10.1149/1945-7111/ad94a9