Smoking timing, genetic susceptibility, and the risk of incident atrial fibrillation: a large prospective cohort study

Our study aimed to analyse the relationship between the time from waking to the first cigarette and incidence of atrial fibrillation (AF), and the modification role of genetic susceptibility.Shorter time from waking to the first cigarette was related to the elevated risk of incident AF.Genetic susceptibility to AF strengthened the gradient inverse association of time from waking to the first cigarette with the incidence of AF.Graphical Abstract