Pharmacokinetic/pharmacodynamic analysis of tedizolid phosphate against Staphylococcus aureusand Streptococcus pneumoniaein children, adolescents, and adults by Monte Carlo simulation

•Label dose tedizolid (TED) was effective for ABSSSIs with MRSA in adolescents/adults.•High-dose TED was preferred for ABSSSIs with (cfr-mediated) linezolid-resistant MRSA.•3 and 4 mg/kg/d of TED were enough for ABSSSIs in 2–6 and 6–12-y-old children.•TED was effective against S. pneumoniaepneumonia, but poor against S. aureus.•TED has poor efficacy against ABSSSIs and pneumonia in neutropenic patients.