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Disruption of bioenergetics enhances the radio-sensitivity of patient-derived glioblastoma tumorspheres
- Source :
- Translational Oncology; January 2025, Vol. 51 Issue: 1
- Publication Year :
- 2025
-
Abstract
- •Bioenergetics regulators enhance the efficacy of radiotherapy in glioblastoma models.•Combined treatment with IR and 2DG alters the GBM transcriptional program.•2DG is the most effective bioenergetic regulator for combined treatment with IR.
Details
- Language :
- English
- ISSN :
- 19447124 and 19365233
- Volume :
- 51
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Translational Oncology
- Publication Type :
- Periodical
- Accession number :
- ejs67958631
- Full Text :
- https://doi.org/10.1016/j.tranon.2024.102197