Factors of the aging process and longevity—selected data

The article presents endogenous and exogenous factors affecting the aging process and longevity, indicating their influence on the epigenome and genome. While discussing endogenous factors, we described genes and protein complexes, metabolic and signaling pathways [IIS (insulin and insulin-like growth factor 1/IGF-1 signaling), ARE/Nrf2 (antioxidant response elements/nuclear factor erythroid-related factor 2), kynurenine/NAD+ (nicotinamide adenine dinucleotide and kynurenine signaling)], and the sirtuin enzyme group and antioxidant enzymes (e.g., SOD1).