Post-Artesunate Delayed Hemolysis in Pediatric Malaria Patients in the United States

Post-artesunate delayed hemolysis (PADH) occurred in 6 of 24 children treated with artesunate for severe malaria in the United States; however, severe hemolysis requiring hospitalization or transfusion was rare. In children in the United States treated with artesunate, counseling, and symptom monitoring may be preferred to weekly laboratory surveillance for PADH.We find that delayed hemolysis is common in children treated with artesunate for severe malaria in the United States. However, severe hemolysis appears rare. Counseling and symptom monitoring may be preferable to weekly laboratory surveillance for PADH in this population.