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Taeniasis impacts human gut microbiome composition and function

Authors :
Mu, Wenjie
Ma, Pingping
Wang, Yugui
Li, Yaqi
Ding, Yingying
Zou, Yang
Pu, Lixia
Yan, Qi
Kong, Haoyue
Guo, Xiaola
Guo, Aijiang
Li, Hailong
Wang, Shuai
Source :
The ISME Journal; January 2024, Vol. 18 Issue: 1
Publication Year :
2024

Abstract

Human taeniasis, caused by Taeniatapeworms, is a global parasitic disease with significant implications for public health and food safety. These tapeworms can grow to considerable sizes and potentially impact the microecology of the host gut. Despite their importance, the effects of Taeniainfection on host gut microbiota haven’t been thoroughly investigated. In this study, we conducted a cross-sectional analysis of the gut microbiome in patients infected with Taenia asiatica(n= 87) compared to healthy controls (n= 79) in the Dali cohort, China. We also performed a longitudinal assessment of microbial changes following deworming in a subset of patients (n= 24). Our findings reveal a significant shift in gut microbial composition, characterized by increased alpha-diversity and an enrichment of Prevotella-driven enterotypes in infected patients compared to healthy controls. The stability of these microbial features post-deworming varied widely among individuals and was lower in those with lower initial alpha diversity and Prevotella-enterotype before deworming. We observed a significant depletion of Bifidobacteriumspecies in infected individuals, regardless of enterotypes, and these prebiotics did not recover post-deworming. Metabolic network analysis and in vitroexperiments suggest that the reduction of Bifidobacteriumwas linked to metabolic competition for ecological niches or nutrients, particularly stachyose, from other microbes rather than the parasitism itself. Furthermore, our machine learning analysis demonstrated that taxa associated with Bifidobacteriumin stachyose metabolism could robustly predict infection but could not predict deworming. This study highlights the substantial impact of taeniasis on the human gut microbiome and overall gut health.

Details

Language :
English
ISSN :
17517362 and 17517370
Volume :
18
Issue :
1
Database :
Supplemental Index
Journal :
The ISME Journal
Publication Type :
Periodical
Accession number :
ejs67896554
Full Text :
https://doi.org/10.1093/ismejo/wrae213