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Zanubrutinib, obinutuzumab, and venetoclax for first-line treatment of mantle cell lymphoma with a TP53mutation

Authors :
Kumar, Anita
Soumerai, Jacob
Abramson, Jeremy S.
Barnes, Jeffrey A.
Caron, Philip
Chhabra, Shalini
Chabowska, Maria
Dogan, Ahmet
Falchi, Lorenzo
Grieve, Clare
Haydu, Julie E.
Johnson, Patrick Connor
Joseph, Ashlee
Kelly, Hailey E.
Labarre, Alyssa
Lue, Jennifer Kimberly
Martignetti, Rosalba
Mi, Joanna
Moskowitz, Alison
Owens, Colette
Plummer, Sean
Puccio, Madeline
Salles, Gilles
Seshan, Venkatraman
Simkins, Elizabeth
Slupe, Natalie
Zhang, Honglei
Zelenetz, Andrew D.
Source :
Blood; 20240101, Issue: Preprints
Publication Year :
2024

Abstract

•BOVen was safe and effective for the frontline treatment of TP53-mutant MCL.•The 2-year progression-free survival of 72% compares favorably with previously reported outcomes with chemoimmunotherapy in TP53-mutant MCL.

Details

Language :
English
ISSN :
00064971 and 15280020
Issue :
Preprints
Database :
Supplemental Index
Journal :
Blood
Publication Type :
Periodical
Accession number :
ejs67802674
Full Text :
https://doi.org/10.1182/blood.2024025563