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A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae and CNS
- Source :
- Nature; 20240101, Issue: Preprints p1-10, 10p
- Publication Year :
- 2024
-
Abstract
- Tissue-selective chemoattractants direct lymphocytes to epithelial surfaces to establish local immune environments, regulate immune responses to food antigens and commensal organisms, and protect from pathogens. Homeostatic chemoattractants for small intestines, colon and skin are known1,2, but chemotropic mechanisms selective for respiratory tract and other non-intestinal mucosal tissues remain poorly understood. Here we leveraged diverse omics datasets to identify GPR25 as a lymphocyte receptor for CXCL17, a chemoattractant cytokine whose expression by epithelial cells of airways, upper gastrointestinal and squamous mucosae unifies the non-intestinal mucosal tissues and distinguishes them from intestinal mucosae. Single-cell transcriptomic analyses show that GPR25is induced on innate lymphocytes before emigration to the periphery, and is imprinted in secondary lymphoid tissues on activated B and T cells responding to immune challenge. GPR25characterizes B and T tissue resident memory cells and regulatory T lymphocytes in non-intestinal mucosal tissues and lungs in humans and mediates lymphocyte homing to barrier epithelia of the airways, oral cavity, stomach, and biliary and genitourinary tracts in mouse models. GPR25is also expressed by T cells in cerebrospinal fluid and CXCL17by neurons, suggesting a role in central nervous system (CNS) immune regulation. We reveal widespread imprinting of GPR25on regulatory T cells, suggesting a mechanistic link to population genetics evidence that GPR25is protective in autoimmunity3,4. Our results define a GPR25–CXCL17 chemoaffinity axis with the potential to integrate immunity and tolerance at non-intestinal mucosae and the CNS.
Details
- Language :
- English
- ISSN :
- 00280836 and 14764687
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Nature
- Publication Type :
- Periodical
- Accession number :
- ejs67777626
- Full Text :
- https://doi.org/10.1038/s41586-024-08043-2