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Incremental eligibility criteria for the BMT CTN 1507 haploidentical trial for children with sickle cell disease

Authors :
John, Tami D.
Walters, Mark C.
Rangarajan, Hemalatha G.
Rahim, Mahvish Q.
McKinney, Christopher
Bollard, Catherine M.
Abusin, Ghada
Eapen, Mary
Kassim, Adetola A.
DeBaun, Michael R.
Source :
Blood Advances; December 2024, Vol. 8 Issue: 23 p6055-6063, 9p
Publication Year :
2024

Abstract

•With DSMB oversight, we introduce a novel stepwise eligibility strategy for pediatric SCD curative trials based on 4 stages.•A committee assessed eligibility based on pain incidence rate, undertreated asthma, chronic stress, and adherence to maximum medical therapy.

Details

Language :
English
ISSN :
24739529 and 24739537
Volume :
8
Issue :
23
Database :
Supplemental Index
Journal :
Blood Advances
Publication Type :
Periodical
Accession number :
ejs67650041
Full Text :
https://doi.org/10.1182/bloodadvances.2024014078