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Difficult-to-Treat Concept in Psoriatic Arthritis: Analysis of 2 Potential Definitions in a Large Group of Patients. A Cross-Sectional Study
- Source :
- Journal of Rheumatology; 2024, Vol. 51 Issue: 10 p985-990, 6p
- Publication Year :
- 2024
-
Abstract
- ObjectiveThe main aim of the study was to evaluate the performance of 2 proposed criteria for difficult-to-treat (D2T) psoriatic arthritis (PsA) in a group of patients and to evaluate the agreement between the 2 sets of criteria.MethodsWe performed a cross-sectional analysis of 2 longitudinal cohorts of patients with PsA fulfilling the Classification Criteria for Psoriatic Arthritis (CASPAR), with at least 1 year of follow-up. A detailed medical history was collected and a physical examination was performed for all recruited patients. The proposed criteria for patients with D2T PsA were applied in our group. To test the performance of the 2 sets of criteria, we used an external validator (absence of patient acceptable symptom state + physician global assessment ≥ 6 cm). Finally, the agreement between the 2 sets of criteria was assessed.ResultsWe evaluated 378 patients with PsA (219 male/159 female), with a mean age (range) of 58 (19-75) years. Seventy-five (19.8%) patients fulfilled the D2T criteria proposed by Perrotta et al and 58 (15.3%) the D2T criteria proposed by Kumthekar et al. Both criteria showed comparable performance, with low sensitivity (Perrotta: 37.8%, Kumthekar: 29.7%) but good specificity (Perrotta: 82.1%, Kumthekar: 86.2%). Finally, the agreement between the 2 sets of criteria is substantial (Fleiss [Formula] 0.72), suggesting that both criteria identify nearly the same group of patients.ConclusionOur study compared 2 published sets of criteria showing comparable performance and substantial agreement. This study may pave the way for further research in this field.
Details
- Language :
- English
- ISSN :
- 0315162X and 14992752
- Volume :
- 51
- Issue :
- 10
- Database :
- Supplemental Index
- Journal :
- Journal of Rheumatology
- Publication Type :
- Periodical
- Accession number :
- ejs67564629
- Full Text :
- https://doi.org/10.3899/jrheum.2024-0101