Chronic lymphocytic leukemia treated successfully by syngeneic marrow transplantation

Marrow transplantation is a potentially curative treatment for patients with lymphohematopoietic malignancies. We report here a case of syngeneic transplantation in a 39‐year‐old male with chemotherapy‐resistant progressive chronic lymphocytic leukemia. Following conditioning therapy with fractionated total body irradiation, etoposide and cyclophosphamide and transplantation from a monozygotic twin brother, the patient achieved a complete remission and remains disease‐free 15 months after transplant. This observation indicates that, in principle, chronic lymphocytic leukemia is a disease curable by marrow transplantation.