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The Pros and Cons of “Machination of Medicine” in Genitourinary Oncology Practice

Authors :
Pederzoli, Filippo
Bandini, Marco
Raggi, Daniele
Ross, Jeffrey S.
Spiess, Philippe E.
Necchi, Andrea
Source :
Bladder Cancer; December 2021, Vol. 7 Issue: 4 p389-393, 5p
Publication Year :
2021

Abstract

The increasing availability of genomic sequencing of tumor tissue in oncology provided valuable insights into tumor evolution and offered clinicians the unprecedented opportunity to tailor therapies on each individual patient, according to the treatment-impacting alterations identified in the tumor cells. In addition to the characterization of somatic alterations in tumor samples, the identification of germline (i.e., constitutional) pathogenic variants can provide additional information to guide informed and personalized therapeutic planning for patients and to enable risk-based screening protocols for at-risk relatives. In genitourinary malignancies, only a few associations between germline mutations and cancer risk and behavior have been thoroughly investigated (e.g., alterations in DNA repair genes in prostate cancer or mutations in Lynch syndrome genes in upper tract urothelial carcinoma). To achieve a wider use of both tumor genomic and germline genetic testing, an integrative approach led by scientific societies is necessary to involve physicians, patients and advocacy groups, to develop a shared strategy to advance the field and provide value-based and reproducible standards of care for patients and their families.

Details

Language :
English
ISSN :
23523727 and 23523735
Volume :
7
Issue :
4
Database :
Supplemental Index
Journal :
Bladder Cancer
Publication Type :
Periodical
Accession number :
ejs67500275
Full Text :
https://doi.org/10.3233/BLC-211514