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Neoadjuvant pembrolizumab plus chemotherapy followed by adjuvant pembrolizumab compared with neoadjuvant chemotherapy alone in patients with early-stage non-small-cell lung cancer (KEYNOTE-671): a randomised, double-blind, placebo-controlled, phase 3 trial
Authors :
Spicer, Jonathan D Garassino, Marina C Wakelee, Heather Liberman, Moishe Kato, Terufumi Tsuboi, Masahiro Lee, Se-Hoon Chen, Ke-Neng Dooms, Christophe Majem, Margarita Eigendorff, Ekkehard Martinengo, Gastón L Bylicki, Olivier Rodríguez-Abreu, Delvys Chaft, Jamie E Novello, Silvia Yang, Jing Arunachalam, Ashwini Keller, Steven M Samkari, Ayman Gao, Shugeng Afanasyev, Sergey Ahmed, Samreen Alekshun, Todd Alves, Gustavo Anderson, Ian Araujo, Luiz Henrique Arkhipov, Alexander Arora, Arvind Bai, Jie Begin, Paul Belonogov, Aleksandr Berard, Henri Berceanu-Ion, Radu Bernabe Caro, Reyes Bondarenko, Igor Bonnet, Reiner Bosch Barrera, Joaquim Brocca, Carlos Bryl, Maciej Bulotta, Alessandra Bylicki, Olivier Calles Blanco, Antonio Carcereny, Enric Carvalho, Leticia Cebotaru, Cristina Chaft, Jamie Charu, Veena Chaves, Fabio Chen, Jun Chen, Ke-Neng Chen, Haiquan Chen, Qixun Chen, Kevin Chiang, Chi-Lu Chiu, Chao-Hua Cicenas, Saulius Ciubotaru, Elena Ciuleanu, Tudor Ciurescu, Ioana Cobb, Patrick Coetzee, Corlia Collins, Dearbhaile Cortinovis, Diego Costas, Kimberly Costin, Dan Cronemberger, Eduardo Henrique Cuevo, Raymund Cuffe, Sinead De Marchi, Pedro Rafael Martins de Paiva Junior, Tadeu Delmonte, Angelo Demedts, Ingel Deschepper, Koenraad Dias, Josiane Dooms, Christophe Duchemann, Boris Dutra, Carolina Duvivier, Herbert Eigendorff, Ekkehard Ernani, Vinicius Faehling, Martin Faria, Luiza Fedenko, Alexander Fernando, Hiran Ferrara, Roberto Ferrari, Vittorio Finley, Gene Fix, Peter Flores, Marcos Fourie, Samuel Franke, Fabio Frohling, Klaus-Peter Furqan, Muhammad Gal, Cristian Galamaga, Robert Ganea, Doina Ganti, Apar Kishor Gao, Shugeng Garassino, Marina Gentzler, Ryan Gianni, Luca Gilli, Marina Girard, Nicolas Goranov, Bojidar Gregorc, Vanesa Greystoke, Alastair Grisanti, Salvatore Grohe, Christian Guarino, Michael Guimaraes, Jose Luiz Guisier, Florian Halmos, Balazs Hammoud, Zane Taysir Han, Ji-Youn Hegmane, Alinta Heng, Fook Yew Horinouchi, Hidehito Horio, Yoshitsugu Hu, Jian Huang, Hsu-Ching Hui, Rina Ikeda, Norihiko Intagliata, Salvatore Iordan, Ingrid Jacobs, Conrad Jain, Kirti Jain, Sushil Jiang, Tao Karaseva, Nina Kato, Terufumi Kaywin, Paul Kazmi, Shayma Keresztes, Roger Khan, Sarah Kim, Jhingook Kolesnik, Olena Kolesnik, Oleksii Kollmeier, Jens Komiya, Takefumi Koontz, Michael Krasnohrud, Yuliia Kristedja, Timothy Kryzhanivska, Anna Kuroda, Hiroaki Laktionov, Konstantin Lambrechts, Marc Lang, Susanne Langleben, Adrian Lee, Se-Hoon Lehmann, Markus Levchenko, Evgeny Levenko, Oleh Li, Shanqing Liao, Bin-Chi Liberman, Moishe Lima, Iane Liu, Geoffrey Liu-Dumlao, Theresa Lo Russo, Giuseppe Lou, Yan Yan Lowczak, Anna Luft, Alexander Ma, Shaohua Majem Tarruella, Margarita Makles, Krytsyna Martinengo, Gaston Martinez Marti, Alex Matias, Danielli Mazieres, Julien Mazilu, Laura Mennecier, Bertrand Migliorino, Maria Rita Misleh, Jamal Molina, Julian Morbeck, Igor Mueller, Annette Muto, Satoshi Nadal Alforja, Ernest Nesterova, Alfiya Nishio, Wataru Niu, Jiaxin Novello, Silvia O'Brien, Mary O'Day, Steven Ogliari, Francesca Okada, Morihito Pang, Yong Kek Paramonov, Viktor Pastor, Andrea Pawlak, Ireneusz Piantedosi, Francovito Pollock, Theodore Pope, Tony Puig, Juan Radhi, Saba Rao, Suman Rathnasabapathy, Chenthilmurugan Reck, Martin Reinacher-Schick, Anke Rich, Patricia Ritgen, Mathias Rittmeyer, Achim Roca, Elisa Rodriguez-Abreu, Delvys Ruff, Paul Rybkin, Igor Saji, Hisashi Sakao, Yukinori Sangal, Ashish Santoro, Armando Sardenberg, Rodrigo Savvides, Panayiotis Scheusan, Roxana Schiller, Joan Schumacher, Lana Serke, Monika Shim, Byoung Yong Shimizu, Junichi Shio, Yutaka Sibille, Anne Siegel, Robert Signorelli, Diego Smagina, Maria Sokur, Iryna Spicer, Jonathan Srkalovic, Gordan Stampleman, Laura Starodub, Alexander Stencel, Katarzyna Sugio, Kenji Surmont, Veerle Suzuki, Hiroyuki Tabacof, Jacques Takamochi, Kazuya Tan, Lijie Tanaka, Fumihiro Tatangelo, Marcelo Täuscher, Dagmar Teixeira, Carlos Thiberville, Luc Trukhin, Dmytro Tsai, Chen-Liang Tsuboi, Masahiro Ungureanu, Andrei Ursol, Grygorii Vanakesa, Tonu Vansteenkiste, Johan Varela, Mirta Villalona-Calero, Miguel Villaruz, Liza Vogel, Gunther Voitko, Nataliia Wakelee, Heather Wang, Qun Wang, Wenxiang Wang, Chin-Chou Wang, Sarah Wehler, Thomas Weksler, Benny Wermke, Martin Wesseler, Claas Wirtz, Hubert Wong, Mark Yan, Xiaolong Yang, Yue Yu, Kong Leong Zasadny, Xavier Zemaitis, Marius Zhang, Lanjun Zhao, Guofang Zhao, Qing Zhu, Yuming Zurawski, Bogdan
Source :
The Lancet; September-October 2024, Vol. 404 Issue: 10459 p1240-1252, 13p
Publication Year :
2024
Abstract
At the first interim analysis of the KEYNOTE-671 trial, adding perioperative pembrolizumab to neoadjuvant chemotherapy significantly improved event-free survival in participants with early-stage non-small-cell lung cancer (NSCLC). We report overall survival and health-related quality of life outcomes from the second interim analysis.
Details
Language :
English
ISSN :
01406736 and 1474547X
Volume :
404
Issue :
10459
Database :
Supplemental Index
Journal :
The Lancet
Publication Type :
Periodical
Accession number :
ejs67482796
Full Text :
https://doi.org/10.1016/S0140-6736(24)01756-2