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Box-Behnken Response Surface Design for the Optimization of a High-Performance Electrochemical Dopamine Sensor Based on Novel Nano-Ag Doped Matériaux Institut Lavoisier Metal-Organic Framework 101 (MIL-101-Cr) Composite Modified Glassy Carbon Electrode

Authors :
Wannassi, Jassem
Missaoui, Nadhem
Tachouaft, Chalal
Mabrouk, Chama
Autret-lambert, Cécile
Bellali, Saher
Echouchene, Fraj
Barhoumi, Houcine
Anouti, Mérièm
Kahri, Hamza
Source :
Journal of the Electrochemical Society; September 2024, Vol. 171 Issue: 9 p097511-097511, 1p
Publication Year :
2024

Abstract

The combination of metal-organic frameworks (MOFs) and metal nanoparticles offers great prospects for improving the electrochemical properties of sensors. In this paper, silver (Ag) nanoparticle-doped metal-organic framework (MIL-101) composites (Ag-MIL-101) were prepared by ultrasonic treatment of MIL-101 and the reduction of the metal precursor (AgNO3) within the MIL-101 material. X-ray diffraction patterns confirmed the formation of Ag-MIL-101(Cr). The resulting material was used to construct a new electrochemical sensor for the reliable detection of dopamine. The electrochemical response of the developed sensor toward dopamine was evaluated using differential pulse voltammetry. A Box-Behnken design was performed, and response surface methodology was used to study the influence of different parameters on dopamine detection. The response of the modified electrode for dopamine detection was linear in the range from 0.02 μM to 10 μM, and the detection limit was 0.02 μM (S/N = 3). Additionally, it showed high selectivity in the presence of urea, uric acid, ascorbic acid, and L-arginine. Due to its low cost, easy process, and great performance, this Ag-MIL-101/GCE electrode can be a good candidate for the fabrication of a non-enzymatic dopamine sensor.

Details

Language :
English
ISSN :
00134651 and 19457111
Volume :
171
Issue :
9
Database :
Supplemental Index
Journal :
Journal of the Electrochemical Society
Publication Type :
Periodical
Accession number :
ejs67469088
Full Text :
https://doi.org/10.1149/1945-7111/ad798a