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Increased CCL2/CCR2 axis promotes tumor progression by increasing M2 macrophages in MYC/BCL2 double-expressor DLBCL
- Source :
- Blood Advances; November 2024, Vol. 8 Issue: 22 p5773-5788, 16p
- Publication Year :
- 2024
-
Abstract
- •The CCL2/CCR2 axis is elevated by MYC and BCL2 via nuclear factor κB p65 in DE-DLBCL.•CCL2/CCR2 axis promotes M2 polarization of macrophage and immunosuppressive environment, being a potential therapeutic target in DE-DLBCL.
Details
- Language :
- English
- ISSN :
- 24739529 and 24739537
- Volume :
- 8
- Issue :
- 22
- Database :
- Supplemental Index
- Journal :
- Blood Advances
- Publication Type :
- Periodical
- Accession number :
- ejs67448525
- Full Text :
- https://doi.org/10.1182/bloodadvances.2024013699