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The effect of alemtuzumab on neurodegeneration in relapsing-remitting multiple sclerosis: A five-year prospective mono-center study

Authors :
Sandgren, Sofia
Novakova, Lenka
Nordin, Anna
Sabir, Hemin
Axelsson, Markus
Malmeström, Clas
Zetterberg, Henrik
Lycke, Jan
Source :
Multiple Sclerosis and Related Disorders; November 2024, Vol. 91 Issue: 1
Publication Year :
2024

Abstract

•We evaluated alemtuzumab (ALZ) effect on neurodegeneration in RRMS.•SyMRI (brain atrophy) and OCT (retinal layer) were used to assess neurodegeneration.•Continued brain and retinal layer atrophy were seen in RRMS with disease activity.•Disease activity free patients showed signs of remyelination.

Details

Language :
English
ISSN :
22110348
Volume :
91
Issue :
1
Database :
Supplemental Index
Journal :
Multiple Sclerosis and Related Disorders
Publication Type :
Periodical
Accession number :
ejs67395321
Full Text :
https://doi.org/10.1016/j.msard.2024.105894