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Ibrutinib plus rituximab and mini-CHOP in older patients with newly diagnosed DLBCL: a phase 2 ALLG study

Authors :
Verner, Emma
Johnston, Amanda
Pati, Nalini
Hawkes, Eliza A.
Lee, Hui-Peng
Cochrane, Tara
Cheah, Chan Yoon
Filshie, Robin
Purtill, Duncan
Sia, Hanlon
Enjeti, Anoop K.
Brown, Christina
Murphy, Nicholas
Curnow, Jennifer
Lee, Kenneth
Gandhi, Maher K.
Walia, Mannu
Butcher, Belinda E.
Trotman, Judith
Lenton, Douglas
Taper, John
Presgrave, Peter
Butler, Jason
Mollee, Peter
Kannourakis, George
Steer, Christopher
Source :
Blood Advances; November 2024, Vol. 8 Issue: 21 p5674-5682, 9p
Publication Year :
2024

Abstract

•Ibrutinib–R-mini-CHOP was a deliverable combination in patients with DLBCL aged ≥75 years.•Ibrutinib–R-mini-CHOP improves PFS compared with historical rates reported for R-mini-CHOP, but this study did not demonstrate a superior OS.

Details

Language :
English
ISSN :
24739529 and 24739537
Volume :
8
Issue :
21
Database :
Supplemental Index
Journal :
Blood Advances
Publication Type :
Periodical
Accession number :
ejs67336244
Full Text :
https://doi.org/10.1182/bloodadvances.2024014035