Polygenic scores for longevity and cognitive performance are associated with predicted brain age in 70-year-olds from the general population.

Genome-wide association studies (GWASs) have shown that several genes, beside the “high-effect” APOE gene, are involved in modulating the risk of dementia and longevity, and some of these genes overlap between the traits. Considering longevity, there are also associations with genes related to other age-related disorders, such as diabetes and cancer. Previous studies have shown associations between genetics of dementia and longevity and measures reflecting brain age, but the vast majority of these studies were performed in age heterogeneous samples. The aim of our study is to investigate how polygenic scores for dementia, general cognitive function, and longevity, associate with predicted biological brain age in 70-year-olds from the general population.