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Impact of PIK3CAgain and PTEN loss on mantle cell lymphoma biology and sensitivity to targeted therapies
- Source :
- Blood Advances; October 2024, Vol. 8 Issue: 20 p5279-5289, 11p
- Publication Year :
- 2024
-
Abstract
- •PIK3CAgain and PTENloss decrease the dependence of MCL cells on BCR signaling and antiapoptotic BCL2.•PIK3CAgain and PTENloss lead to complex metabolic rewiring and increased survival of MCL cells under hypoxia.
Details
- Language :
- English
- ISSN :
- 24739529 and 24739537
- Volume :
- 8
- Issue :
- 20
- Database :
- Supplemental Index
- Journal :
- Blood Advances
- Publication Type :
- Periodical
- Accession number :
- ejs67262049
- Full Text :
- https://doi.org/10.1182/bloodadvances.2024013205