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Altered enhancer-promoter interaction leads to MNX1expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13)
- Source :
- Blood Advances; October 2024, Vol. 8 Issue: 19 p5100-5111, 12p
- Publication Year :
- 2024
-
Abstract
- •Expression analysis of >1500 pediatric AML samples demonstrates MNX1expression as a universal feature of t(7;12)(q36;p13) AML.•MNX1is activated by an enhancer-hijacking event in t(7;12)(q36;p13) AML and not, as previously postulated, by an MNX1::ETV6oncofusion.
Details
- Language :
- English
- ISSN :
- 24739529 and 24739537
- Volume :
- 8
- Issue :
- 19
- Database :
- Supplemental Index
- Journal :
- Blood Advances
- Publication Type :
- Periodical
- Accession number :
- ejs67144200
- Full Text :
- https://doi.org/10.1182/bloodadvances.2023012161