Back to Search Start Over

Purification of ursolic acid and β-sitosterol from endophytic Alternaria alternatafor their alpha-amylase inhibitory activity

Authors :
Dwibedi, Vagish
Mishra, Shashank Shekher
George, Nancy
Joshi, Mahavir
Kaur, Gursharan
Gupta, Mukul
Rath, Santosh Kumar
Source :
Journal of Biomolecular Structure and Dynamics; September 2024, Vol. 42 Issue: 13 p6688-6699, 12p
Publication Year :
2024

Abstract

AbstractFungal endophytes are a known warehouse of bioactive compounds with multifarious applications. In the present investigation two compounds, β-Sitosterol (1) and ursolic acid (2), were isolated from Alternaria alternata, an endophytic fungus associated with Morus albaLinn for the first time. The structure of the compounds was elucidated on the basis of comprehensive spectral analysis (UV, IR, 1 H-, 13 C- and 2D-NMR, as well as HRESI–MS). In the in vitroalpha amylase inhibitory assay both compounds (1) and (2) show potent antidiabetic activity. In support, Docking studies indicate significant binding affinity of the isolated compounds. Hence from the present study, it can be concluded that endophytic fungi in Morus albaLinn can find use in antidiabetic drug development in the medicinal industry.Communicated by Ramaswamy H. Sarma

Details

Language :
English
ISSN :
07391102 and 15380254
Volume :
42
Issue :
13
Database :
Supplemental Index
Journal :
Journal of Biomolecular Structure and Dynamics
Publication Type :
Periodical
Accession number :
ejs67128885
Full Text :
https://doi.org/10.1080/07391102.2023.2236717