Back to Search
Start Over
Hydrazone Phosphaketene as a Synthetic Platform To Obtain Three Classes of 1,2,4-Diazaphosphol Derivatives by Switchable Chemoselectivity Strategies
- Source :
- Organic Letters; May 2024, Vol. 26 Issue: 17 p3575-3580, 6p
- Publication Year :
- 2024
-
Abstract
- We introduce switchable chemoselectivity strategies based on the hydrazone phosphaketene intermediate to synthesize three classes of 1,2,4-diazaphosphol derivatives. First, the five-membered heterocyclic P and O anion intermediates acted as nucleophilic agents in the selective construction of C–P and C–O bonds. Second, the phosphinidene served as a phosphorus synthon, allowing for the formation of C–P and C–N bonds. Finally, a stepwise mechanism, supported by DFT calculations, was invoked to explain the reaction selectivity.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 26
- Issue :
- 17
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs67017098
- Full Text :
- https://doi.org/10.1021/acs.orglett.4c00993