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NK- and T-cell repertoire is established early after allogeneic HSCT and is imprinted by CMV reactivation

Authors :
Schäfer, Antonia
Calderin Sollet, Zuleika
Hervé, Marie-Priscille
Buhler, Stéphane
Ferrari-Lacraz, Sylvie
Norman, Paul J.
Kichula, Katherine M.
Farias, Ticiana D. J.
Masouridi-Levrat, Stavroula
Mamez, Anne-Claire
Pradier, Amandine
Simonetta, Federico
Chalandon, Yves
Villard, Jean
Source :
Blood Advances; November 2024, Vol. 8 Issue: 21 p5612-5624, 13p
Publication Year :
2024

Abstract

•The TCR and NK-cell repertoire establish within the first 90 days after transplantation.•CMV reactivation is associated with enhanced TCR clonality and a shift toward enhanced maturation and functionality of NK cells.

Details

Language :
English
ISSN :
24739529 and 24739537
Volume :
8
Issue :
21
Database :
Supplemental Index
Journal :
Blood Advances
Publication Type :
Periodical
Accession number :
ejs67001889
Full Text :
https://doi.org/10.1182/bloodadvances.2024013117