Clinical Outcomes and Targeted Genomic Analysis of Renal Cell Carcinoma Brain Metastases Treated with Stereotactic Radiosurgery

To our knowledge, this is the largest study investigating mutational profiles of renal cell carcinoma brain metastases (BMs) and the only such study with annotated intracranial outcomes. Stereotactic radiosurgery (SRS) provides durable in-field local control of BMs, and recognition of pseudoprogression following SRS is crucial to ensuring appropriate management. The incidence of PI3Kpathway alterations are enriched in BM+ patients compared with BM– patients and warrants further investigation.