Late Life Depression is Not Associated With Alzheimer-Type Tau: Preliminary Evidence From a Next-Generation Tau Ligand PET-MR Study

•What is the primary question addressed by this study?This study investigated if tau accumulation is higher in late life depression (LLD) than in a healthy comparison group and in patients with mild cognitive impairment due to Alzheimer's (MCI).•What is the main finding of this study?LLD patients exhibited lower gray matter volume than the comparison group in temporal regions but similar tau accumulation, in contrast to mild cognitive impairment due to Alzheimer's (MCI) patients who showed significantly higher tau burden.•What is the meaning of the finding?Alzheimer associated tau pathology is unlikely to contribute to lower gray matter volume in major depressive disorder in older adults.