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Longitudinal Analyses of Circulating Tumor DNA for the Detection of EGFRMutation-Positive Advanced NSCLC Progression During Treatment: Data From FLAURA and AURA3
- Source :
- Journal of Thoracic Oncology; 20240101, Issue: Preprints
- Publication Year :
- 2024
-
Abstract
- EGFR tyrosine kinase inhibitor (EGFR-TKI)-sensitizing and -resistance mutations may be detected in plasma through circulating tumor DNA (ctDNA). Circulating tumor DNA level changes reflect alterations in tumor burden and could be a dynamic indicator of treatment effect. This analysis aimed to determine whether longitudinal EGFR-mutation ctDNA testing could detect progressive disease (PD) before radiologic detection.
Details
- Language :
- English
- ISSN :
- 15560864 and 15561380
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Journal of Thoracic Oncology
- Publication Type :
- Periodical
- Accession number :
- ejs66942318
- Full Text :
- https://doi.org/10.1016/j.jtho.2024.07.008