TWO-YEAR'S WORSENING OF SEMI-QUANTITATIVE MRI FEATURES AS SURROGATE OUTCOMES FOR LONG-TERM INCIDENT RADIOGRAPHIC KNEE OSTEOARTHRITIS AFTER ACL-RUPTURE

With an annual incidence rate of 2-5% in high-risk populations, the use of established knee OA as an outcome challenges the feasibility of preventive OA research. Therefore, valid surrogate outcomes, for which short-term changes capture long-term OA incidence, are urgently needed.