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Direct and indirect mechanisms mediating apoptosis during HIV infection: contribution to in vivoCD4 T cell depletion
- Source :
- Seminars in Immunology; June 1993, Vol. 5 Issue: 3 p187-194, 8p
- Publication Year :
- 1993
-
Abstract
- The gradual depletion of CD4+T lymphocytes during the development of AIDS may be due, at least in part, to a process referred to as apoptosis. This process involves a Ca2+dependent nuclear endonuclease that cleaves the chromatin at internucleosomal junctions. In addition, we have recently provided evidence that apoptosis may be responsible not only for the progressive loss of CD4+T lymphocytes but may be operative in CD8+T lymphocytes as well. Here, we describe mechanisms which by direct and indirect pathways may induce apoptosis during HIV infection and thus leading to elimination of T cells.
Details
- Language :
- English
- ISSN :
- 10445323 and 10963618
- Volume :
- 5
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Seminars in Immunology
- Publication Type :
- Periodical
- Accession number :
- ejs666496
- Full Text :
- https://doi.org/10.1006/smim.1993.1022