Macahuilettiin A, a new isoprenylated flavanone from the leaves of Macaranga hullettiiKing ex Hook and their antiplasmodial activity

A new isoprenylated flavanone, macahuilettiin A (1), along with lonchocarpol A (2) and nymphaeol C (3), were isolated from Macaranga hullettiiKing ex Hook leaves. Their structures were combined by UV, high‐resolution ESI‐TOFMS, 1D‐, and 2D‐NMR spectra analysis. Flavanones 1–3were assayed for antiplasmodial activity toward Plasmodium falciparum3D7, which was carried out using the Trager and Jansen method, showing that the IC50values for flavanones 1–3were 0.15, 1.64, and 0.61 µm, respectively, which is classified as high activity.