The prevalent dynamic and genetic characterization of mcr-1encoding multidrug resistant Escherichia colistrains recovered from poultry in Hebei, China

•The genetic environment of mcr-1showed its position on the p0111 plasmid in 2 isolates, a rarely reported plasmid type for the mcr-1gene. Moreover, this type of plasmids was transferable in recipient J53, and mcr-1was encoded by three mobile elements ISApl1, Tn3, and IS26, forming a novel backbone Tn3–IS26-mcr-1–pap2-ISApl1 on the p0111 plasmid.•Four O15: H10-serotype Escherichia coli(E. coli) carrying the mcr-1gene have been identified in this study.•The mcr-1gene can transfer horizontally with much stability in this study.•The mcr-1gene from the present study has homology with mcr-1 E. colifrom other sources, showing its clonal dissemination among the different hosts and species, which poses a potential threat to public health.