Inhibition of EGFR1 in Triple Negative Breast Cancer Cells Using siRNA Loaded with Fe3O4Magnetic Nanoparticles

Authors :: Parnian, Javad
Ma’mani, Leila
Bakhtiari, Mohamad Reza
Safavi, Maliheh
Source :: BioNanoScience; 20240101, Issue: Preprints p1-13, 13p
Publication Year :: 2024
Abstract: Graphical Abstract: The fate of the siRNA@[Fe<subscript>3</subscript>O<subscript>4</subscript>@βCD-PEI/FA-PEG] complex after endocytosis. (1) siRNA@[Fe<subscript>3</subscript>O<subscript>4</subscript>@βCD-PEI/FA-PEG] entering the cell (early endosome) through endocytosis. (2) Entry of siRNA@[Fe<subscript>3</subscript>O<subscript>4</subscript>@βCD-PEI/FA-PEG] into the late endosome. (3a) Endosomal escape and cargo survival (siRNA). (3b) Lysosomal digestion pathway. (4) Release of siRNA to cytosol and interaction with RISC after rupture of endosome membrane. (5) mRNA degradation and EGFR1 gene silencing

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