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Nuclear receptor Rev-erbα role in fine-tuning erythropoietin gene expression
- Source :
- Blood Advances; July 2024, Vol. 8 Issue: 14 p3705-3717, 13p
- Publication Year :
- 2024
-
Abstract
- •EPO is crucial for maintaining RBC balance, and its dysregulation can cause conditions such as anemia and polycythemia.•This study reveals a new discovery that 2 NRs, Rev-erbα and RORα, act oppositely, suggesting a potential therapy for EPO-related disorders.
Details
- Language :
- English
- ISSN :
- 24739529 and 24739537
- Volume :
- 8
- Issue :
- 14
- Database :
- Supplemental Index
- Journal :
- Blood Advances
- Publication Type :
- Periodical
- Accession number :
- ejs66392661
- Full Text :
- https://doi.org/10.1182/bloodadvances.2023012228