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Fit-for-Purpose Ki-67 Immunohistochemistry Assays for Breast Cancer
- Source :
- Laboratory Investigation; 20240101, Issue: Preprints
- Publication Year :
- 2024
-
Abstract
- New therapies are being developed for breast cancer and in this process some “old” biomarkers are re-utilized and given a new purpose. It is not always recognized that, by changing a biomarker’s intended use, a new biomarker assay is created. The Ki-67 biomarker is typically assessed by immunohistochemistry (IHC) to provide a proliferative index in breast cancer. Canadian laboratories assessed the analytical performance and diagnostic accuracy of their Ki-67 IHC laboratory developed tests (LDTs), of relevance for the LDTs’ clinical utility.
Details
- Language :
- English
- ISSN :
- 00236837 and 15300307
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Laboratory Investigation
- Publication Type :
- Periodical
- Accession number :
- ejs66324391
- Full Text :
- https://doi.org/10.1016/j.labinv.2024.102076