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Multiple Ca 2+signaling pathways converge on CaM kinase in PC12 cells
- Source :
- FEBS Letters; January 1992, Vol. 304 Issue: 2 p237-240, 4p
- Publication Year :
- 1992
-
Abstract
- The role of multifunctional Ca 2+/calmodulin-dependent protein kinase (CaM kinase) in mediating various Ca 2+signaling pathways was examined in PC12 cells. Conversion of the kinase to a Ca 2+-independent form was used to monitor which neurotransmitters activate the enzyme in situ. CaM kinase responds to Ca 2+influx elicited by ligand-gated Ca 2+channels for ATP and acetylcholine. It also responds to Ca 2+mobilization ofIP 3-sensitive stores elicited by phospholipase C-linked receptors for ATP and acetylcholine as well as by caffeine. CaM kinase mediates the actions of many neurotransmitters and Ca 2+signaling pathways.
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 304
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- FEBS Letters
- Publication Type :
- Periodical
- Accession number :
- ejs66309925
- Full Text :
- https://doi.org/10.1016/0014-5793(92)80627-S