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O-glycan determinants regulate VWF trafficking to Weibel-Palade bodies
- Source :
- Blood Advances; 20240101, Issue: Preprints
- Publication Year :
- 2024
-
Abstract
- 1.VWF O-glycans critically influence VWF biosynthesis and trafficking into Weibel-Palade bodies in human endothelial cells.2.O-glycan inhibition leads to VWF A1 domain activation and formation of significantly smaller Weibel-Palade bodies.
Details
- Language :
- English
- ISSN :
- 24739529 and 24739537
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Blood Advances
- Publication Type :
- Periodical
- Accession number :
- ejs66149615
- Full Text :
- https://doi.org/10.1182/bloodadvances.2023012499