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Preconceptional maternal hyperandrogenism and metabolic syndrome risk in male offspring: a long-term population-based study

Authors :
Noroozzadeh, M.
Rahmati, M.
Amiri, M.
Saei Ghare Naz, M.
Azizi, F.
Ramezani Tehrani, F.
Source :
Journal of Endocrinological Investigation; November 2024, Vol. 47 Issue: 11 p2731-2743, 13p
Publication Year :
2024

Abstract

Purpose: There is limited research on the effects of maternal hyperandrogenism (MHA) on cardiometabolic risk factors in male offspring. We aimed to compare the risk of metabolic syndrome (MetS) in sons of women with preconceptional hyperandrogenism (HA) to those of non-HA women in later life. Methods: Using data obtained from the Tehran Lipid and Glucose Cohort Study, with an average of 20 years follow-up, 1913 sons were divided into two groups based on their MHA status, sons with MHA (n = 523) and sons without MHA (controls n = 1390). The study groups were monitored from the baseline until either the incidence of events, censoring, or the end of the study period, depending on which occurred first. Age-scaled unadjusted and adjusted Cox regression models were utilized to evaluate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between MHA and MetS in their sons. Results: There was no significant association between MHA and HR of MetS in sons with MHA compared to controls, even after adjustment (unadjusted HR (95% CI) 0.94 (0.80–1.11), P= 0.5) and (adjusted HR (95% CI) 0.98 (0.81–1.18),P= 0.8). Sons with MHA showed a HR of 1.35 for developing high fasting blood sugar compared to controls (unadjusted HR (95% CI) 1.35 (1.01–1.81), P= 0.04), however, after adjustment this association did not remain significant (adjusted HR (95% CI) 1.25 (0.90–1.74), P= 0.1). Conclusion: The results suggest that preconceptional MHA doesn’t increase the risk of developing MetS in sons in later life. According to this suggestion, preconceptional MHA may not have long-term metabolic consequences in male offspring.

Details

Language :
English
ISSN :
03914097 and 17208386
Volume :
47
Issue :
11
Database :
Supplemental Index
Journal :
Journal of Endocrinological Investigation
Publication Type :
Periodical
Accession number :
ejs66145343
Full Text :
https://doi.org/10.1007/s40618-024-02374-7