Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype

In this study, Nuechterlein et al. show that the deficiency of phosphodiesterase PDE10A activates PI3K/AKT/mTOR signaling independent of PTEN and promotes proneural-to-mesenchymal transition and gliomagenesis. Their work highlights that PDE10A may function as a potential tumor suppressor and that PDE10A-deficient glioblastomas may be therapeutically vulnerable to PI3K inhibition.