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A clinical impact study of dermatologists' use of diagnostic gene expression profile testing to guide patient management
- Source :
- Melanoma Management; April 2024, Vol. 11 Issue: 1
- Publication Year :
- 2024
-
Abstract
- Aim:Cutaneous melanocytic neoplasms with diagnostic and/or clinical ambiguity pose patient management challenges. Methods:Six randomized case scenarios with diagnostic/clinical uncertainty were described with/without a benign or malignant diagnostic gene expression profile (GEP) result. Results:Clinical impact was assessed by reporting the mean increase/decrease of management changes normalized to baseline (n = 32 dermatologists). Benign GEP results prompted clinicians to decrease surgical margins (84.2%). Malignant GEP results escalated surgical excision recommendations (100%). A majority (72.2%) reduced and nearly all (98.9%) increased follow-up frequency for benign or malignant GEP results, respectively. There was an overall increase in management plan confidence with GEP results. Conclusion:Diagnostic GEP tests help guide clinical decision-making in a variety of diagnostically ambiguous or clinicopathologically discordant scenarios.
Details
- Language :
- English
- ISSN :
- 20450885 and 20450893
- Volume :
- 11
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Melanoma Management
- Publication Type :
- Periodical
- Accession number :
- ejs66102600
- Full Text :
- https://doi.org/10.2217/mmt-2023-0002